NSC 177223

Catalogue number: N900270
Chemical name: NSC 177223
Synonyms: 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide; API-1
CAS Number: 36707-00-3
Possible CAS #: NA
Molecular form.: C₁₃H₁₅N₅O₆
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 337.29
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Apoptosis, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: NSC 177223 is a Akt/protein kinase B inhibitor. It binds to pleckstrin homologous domain of Akt and blocks Akt membrane translocation. Treatment of cancer cells with NSC 177223 results in inhibition of the kinase activities and induction of cell growth arrest and apoptosis selectively in human cancer cells that harbor constitutively activated Akt.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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