N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester

Catalogue number: N497030
Chemical name: N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester
Synonyms:
CAS Number: 1256490-31-9
Possible CAS #: NA
Molecular form.: C₁₈H₂₁N₂O₇P
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 408.34
Storage: No Data Available
Solubility: Dichloromethane, Ethyl Acetate, Methanol
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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Inventory Status:   Pending QC

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