Catalogue number: N493695
Chemical name: S-(4-Nitrobenzyl)-6-thioinosine
Synonyms: 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine; 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine; S-(p-Nitrobenzyl)-6-mercapto -9-β-D-ribofuranosylpurine; NBMPR; NSC 296962;
CAS Number: 38048-32-7
Possible CAS #: NA
Molecular form.: C₁₇H₁₇N₅O₆S
Appearance: Off-White Solid
Melting Point: 177-180°C
Mol. Weight: 419.41
Storage: Refrigerator
Solubility: DMSO, Ethyl Acetate, Methanol
Stability: No Data Available
Category: Heterocycles, Inhibitors, Nucleotides, Bases & Related Reagents, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardioprotective, and neuroprotective agents.
Dangerous Goods Info: NA
References: Krug, E., et al.: J. Biol. Chem., 264, 10601 (1989), Griffiths, M., et al.: Biochem. J., 328, 739 (1997), Zhu, Z., et al.: J. Med. Chem., 46, 831 (2003), Baldwin, S., et al.: J. Biol. Chem., 280, 15880 (2005), Barnes, K., et al.: Circ. Res., 99, 510 (2006),
Peer Review Product Citations:

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