Catalogue number: N481002
Chemical name: rac-Niranthin-d4
Synonyms: (R*,R*)-6-[4-(3,4-Dimethoxyphenyl)-2,3-bis(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole-d4; rel-6-[(2R,3R)-4-(3,4-Dimethoxyphenyl)-2,3-bis(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole-d4;
CAS Number: NA
Possible CAS #: Unlabelled: 50656-77-4
Molecular form.: C₂₄H₂₈D₄O₇
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 436.53
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Labelled rac-Niranthin is a lignan compound isolated from the plant Phyllanthus amarus and shows anti-leishmanial activity. It acts through induction of topoisomerase I-mediated DNA-protein adduct formation in Leishmania cells triggering apoptosis of cellular nucleases. It also maintains the ability to reduce uric acid concentrations through xanthine oxidase inhibition.
References: Chowdhury, S. et al.: EMBO Mol. Med., 4, 1126 (2012); Murugaiyah, V. et al.: J. Ethnopharm., 124, 233 (2009);
Dangerous Goods Info: NA

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