Catalogue number: N388752
Chemical name: trans-Ned-19-d8
Synonyms: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-(piperazinyl-d8)]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic Acid;
CAS Number: NA
Possible CAS #: unlabelled: 1137263-70-7 (for relative stereochem)
Molecular form.: C₃₀H₂₃D₈FN₄O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 522.64
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Heterocycles, Indole Derivatives, Inhibitors, Isotope Labelled Compounds, Fluorescent Labels & Indicators, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Labelled trans-Ned-19, a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. trans-Ned-19 inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM) and also inhibits [32P]NAADP binding (IC50 = 0.4 nM). trans-Ned-19 can be used as a chemical proble since it fluorescentey labels NAADP receptors in intact cells.
Dangerous Goods Info: NA
References: Rosen, D. et al.: J. Biol. Chem., 284, 34930 (2009); Naylor, E. et al.: Nat. Chem. Biol., 5, 220 (2009); Thai, T.L. et al.: Am. J. Physiol. Renal Physiol., 297, F510 (2009);
Peer Review Product Citations:

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