Catalogue number: N388550
Chemical name: Necrostatin-1
Synonyms: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; 5-(Indol-3-ylmethyl)-3-methyl-2-thiohydantoin; Nec 1;
CAS Number: 4311-88-0
Possible CAS #: NA
Molecular form.: C₁₃H₁₃N₃OS
Appearance: Yellow Solid
Melting Point: 153-155°C
Mol. Weight: 259.33
Storage: Refrigerator
Solubility: DMSO, Methanol
Stability: No Data Available
Category: Aromatics, Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.
References: Foresti, R., et al: J. Biol. Chem., 272, 18411 (1997); Cardenas, A., et al.: J. Neurochem., 74, 2041 (2000); Degterev, et al.: Nat. Chem. Biol., 1, 112 (2005); Hitomi, J., et al.: Cell, 135, 1311 (2008);
Dangerous Goods Info: NA

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  Pack size Price(USD)
5mg $45.00
25mg $90.00
100mg $250.00
  Pack size Price(USD)
10mg $45.00
50mg $150.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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