Necrostatin-1

Catalogue number: N388550
Chemical name: Necrostatin-1
Synonyms: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; 5-(Indol-3-ylmethyl)-3-methyl-2-thiohydantoin; Nec 1;
CAS Number: 4311-88-0
Possible CAS #: NA
Molecular form.: C₁₃H₁₃N₃OS
Appearance: Yellow Solid
Melting Point: 153-155°C
Mol. Weight: 259.33
Storage: Refrigerator
Solubility: DMSO, Methanol
Stability: No Data Available
Category: Aromatics, Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells. Necrostatin-1 has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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Inventory Status:   Pending QC

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