Catalogue number: N381200
Chemical name: NB-851
Synonyms: (4S)-4-[(1R)1-Hydroxy-2-[[1-[3-(1-methylethyl)phenyl]cyclopropyl]amino]ethyl]-19-methyl-11,16-dioxa-3,18-diazatricyclo[,10]docosa-1(21),6,8,10(22),17,19-hexaen-2-one; (4S)-4-[(1R)-1-Hydroxy-2-[[1-(3-isopropylphenyl)cyclopropyl]amino]ethyl]-19-methyl-11,16-dioxa-3,18-diazatricyclo[,10]docosa-1(21),6,8,10(22),17,19-hexaen-2-one;
CAS Number: 943925-09-5
Possible CAS #: NA
Molecular form.: C₃₃H₄₁N₃O₄
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 543.7
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Intermediates, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: NB-851 is a macrocyclic BACE-1 inhibitor reducing Aβ in brain after administration. Potential treatment for the prevention or maintenance of Alzheimer’s disease.
Dangerous Goods Info: NA
References: Lerchner, A. et al.: Bioorg. Med. Chem. Lett., 20, 603 (2010);
Peer Review Product Citations:

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