Myriocin

Catalogue number: M884400
Chemical name: Myriocin
Synonyms: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R*,3S*,4S*,6E)]-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; Thermozymocidin; (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic Acid;
CAS Number: 35891-70-4
Possible CAS #: NA
Molecular form.: C₂₁H₃₉NO₆
Appearance: White to Off-White Solid
Melting Point: >175°C (dec.)
Mol. Weight: 401.54
Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility: DMSO (Sparingly), Methanol
Stability: No Data Available
Category: Aliphatics, Apoptosis, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Myriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin is a useful biochemical research tool for depleting cells of sphingolipids.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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50mg $325.00
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