Mithramycin A

Catalogue number: M369500
Chemical name: Mithramycin A
Synonyms: [1S(2S,3S)]-5-Deoxy-1-C-[7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-lyxo-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose; Mithramycin; A 2371; Antibiotic LA 7017; Aureolic Acid; Mithracin; Mitramycin; NSC 24559; PA 144; Plicamycin; Plicatomycin;
CAS Number: 18378-89-7
Possible CAS #: NA
Molecular form.: C₅₂H₇₆O₂₄
Appearance: Yellow Solid
Melting Point: >173ºC (dec.)
Mol. Weight: 1085.15
Storage: -20˚C Freezer, Under Inert Atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Aromatics, Carbohydrates & Derivatives, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Mithramycin A inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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