3’-Methoxy-4’,5,7-trihydroxyisoflavone

Catalogue number: M269675
Chemical name: 3’-Methoxy-4’,5,7-trihydroxyisoflavone
Synonyms: 5,7-Dihydroxy-3-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one; 3’-Methylorobol; 3’-O-Methylorobol; Orobol 3’-Methyl Ether
CAS Number: 36190-95-1
Possible CAS #: NA
Molecular form.: C₁₆H₁₂O₆
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 300.26
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: 3’-Methoxy-4’,5,7-trihydroxyisoflavone is a derivative of Genistein (G350000); a compound that exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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