6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid

Catalogue number: M264215
Chemical name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid
Synonyms: GKA 50
CAS Number: 851884-87-2
Possible CAS #: NA
Molecular form.: C₂₆H₂₈N₂O₆
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 464.51
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Enzyme Substrates, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals,Protein Kinase Inhibitors and Activators
Boiling Point: No Data Available
Applications: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic Acid, is one of the glucokinase activator derivatives. GKAs activate GK via binding to an allosteric site of the enzyme. They increase glucose-stimulated insulin secretion and decrease blood glucose levels. Also, glucokinase activator GKA50 is shown to be able to promote proliferation by increasing the cell volume and thus, preventing apoptosis in rat pancreatic insulinoma-1 beta cell.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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