L-Methionine [R,S]-Sulfoximine-13C5

Catalogue number: M260502
Chemical name: L-Methionine [R,S]-Sulfoximine-13C5
Synonyms: L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine-13C5; (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic Acid-13C5;
CAS Number: NA
Possible CAS #: NA
Molecular form.: ¹³C₅H₁₂N₂O₃S
Appearance: White Solid
Melting Point: >203°C (dec.)
Mol. Weight: 185.19
Storage: -20°C Freezer
Solubility: Water
Stability: No Data Available
Category: Amino Acids & Derivatives, Isotope Labelled Compounds, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: L-Methionine [R,S]-Sulfoximine-13C5,15N is the isotope labelled analog of L-Methionine [R,S]-Sulfoximine. Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM). Methionine sulfoximine is also a toxic byproduct of nitrogen trichloride, a compound that was used to bleach unprocessed wheat flour prior to 1968. The compound has been investigated as a potential neurotoxin linked to diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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