L-Methionine [R,S]-Sulfoximine-13C5

Catalogue number: M260502
Chemical name: L-Methionine [R,S]-Sulfoximine-13C5
Synonyms: L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine-13C5; (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic Acid-13C5;
CAS Number: NA
Possible CAS #: 15985-39-4 unlabelled
Molecular form.: ¹³C₅H₁₂N₂O₃S
Appearance: White Solid
Melting Point: >203°C (dec.)
Mol. Weight: 185.19
Storage: -20°C Freezer
Solubility: Water
Stability: No Data Available
Category: Amino Acids & Derivatives, Isotope Labelled Compounds, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: L-Methionine [R,S]-Sulfoximine-13C5,15N is the isotope labelled analog of L-Methionine [R,S]-Sulfoximine. Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM). Methionine sulfoximine is also a toxic byproduct of nitrogen trichloride, a compound that was used to bleach unprocessed wheat flour prior to 1968. The compound has been investigated as a potential neurotoxin linked to diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease.
References: Griffith, O.W., and Meister, A.: J. Biol. Chem. 254, 7558 (1979), Willard-Mack, C.L., et al: Neuroscience, 71, 2, 589 (1996)
Dangerous Goods Info: NA

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  Pack size Price(USD)
1mg $250.00
  Pack size Price(USD)
10mg $2000.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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