Lometrexol

Catalogue number: L469465
Chemical name: Lometrexol
Synonyms: N-[4-[2-[(6R)-2-Amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-L-glutamic Acid; LY 264618;
CAS Number: 106400-81-1
Possible CAS #: NA
Molecular form.: C₂₁H₂₅N₅O₆
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 443.45
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: It is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo purine synthesis. Lometrexol has activity against tumors which are refractory to other drugs, notably Methotrexate.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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