LEE011-d6

Catalogue number: L321002
Chemical name: LEE011-d6
Synonyms: 7-Cyclopentyl-N,N-di(methyl-d3)-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide
CAS Number: 1328934-40-2
Possible CAS #: NA
Molecular form.: C₂₃H₂₄D₆N₈O
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 440.57
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Isotope Labelled Compounds, Amines, Aromatics, Heterocycles, Inhibitors
Boiling Point: No Data Available
Applications: LEE011-d6 is the isotope analog of LEE011(L321000). LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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