4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (1.0 mg/mL in Methanol)

Catalogue number: KIT0575
Chemical name: 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (1.0 mg/mL in Methanol)
Synonyms: 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; NNK;
CAS Number: 64091-91-4
Possible CAS #: NA
Molecular form.: C₁₀H₁₃N₃O₂
Appearance: Clear Colourless Solution
Melting Point: N/A
Mol. Weight: 207.23
Storage: -20°C Freezer
Solubility: Methanol
Stability: No Data Available
Category: Aromatics, Mutagenesis Research Chemicals, Nicotine Derivatives,
Boiling Point: No Data Available
Applications: General Uses: Nicotine Testing, Environmental Monitoring and testing of nicotine biomarkers. Description: The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a powerful lung carcinogen in animal models at a dose of 25mg/kg body weight (1) . NNK is considered “carcinogenic to humans” by the International Agency for Research on Cancer (2). NNK induce carcinogenesis by causing DNA adductions and mutations as well as promoting tumor growth through receptor-mediated effects (3). Nicotine can undergo chemical conversions into carcinogenic NNK during the process of curing & smoking (4) .
Dangerous Goods Info: Not a dangerous good if item is equal too or less than 1g/ml and there is less than 100g in the package
References: 1. Ye, B. BMC Cancer.(2007); 29:7:90
2. International Agency for Research on Cancer (2012) Vol. 100E, IARC, France.
3. Takahashi, H. et al. Cancer Cell. (2010);17:89–97.
4. Hukkanen J., et al. Pharmacol. Rev. (2005); 57: 79–115.
Peer Review Product Citations: 1) Aizawa K. et. al, 2016. Int J Cancer. 1;139(5):1171-81. PMID: 27116542
2) Narayanapillai SC, et. al, 2016. Chem Res Toxicol. PMID: 27728767
3) Moghbel N. et. al, 2016. Toxicol Lett. 8;254:45-51 PMID: 27178269
4) Narauanapillai SC, et al, 2016. Drug Metab Dispos. 44(3):422-7. PMID: 26744252

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  Pack size Price(USD)
51mL $110.00
  Pack size Price(USD)
Exact Weight Packaging ($75(USD) / Vial)
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