Catalogue number: J211325
Chemical name: JW-55
Synonyms: N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide;
CAS Number: 664993-53-7
Possible CAS #: NA
Molecular form.: C₂₅H₂₆N₂O₅
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 434.48
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.
Dangerous Goods Info: NA
References: Waaler, et al., et al.: Cancer Res., 72, 2822 (2012);
Peer Review Product Citations: Waaler, et al., et al.: Cancer Res., 72, 2822 (2012);

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  Pack size Price(USD)
10mg $140.00
  Pack size Price(USD)
100mg $1120.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Available in 2-3 weeks

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