Janex 1

Catalogue number: J210400
Chemical name: Janex 1
Synonyms: 4-(4’-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline; WHI-P 131
CAS Number: 202475-60-3
Possible CAS #: NA
Molecular form.: C₁₆H₁₅N₃O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 297.31
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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