J 147

Catalogue number: J210300
Chemical name: J 147
Synonyms: 2,2,2-Trifluoroacetic Acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl) methylene]hydrazide;
CAS Number: 1146963-51-0
Possible CAS #: NA
Molecular form.: C₁₈H₁₇F₃N₂O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 350.33
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer’s disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer’s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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