IWR-1

Catalogue number: I941800
Chemical name: IWR-1
Synonyms: rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide;
CAS Number: 1127442-82-3
Possible CAS #: NA
Molecular form.: C₂₅H₁₉N₃O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 409.44
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b). Such compounds may be used in the treatment of Wnt protein signaling-related diseases and conditions such as cancer, degenerative diseases, type II diabetes and osteopetrosis.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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