1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride

Catalogue number: I882200
Chemical name: 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride
Synonyms: HA1077, Fasudil
CAS Number: 103745-39-7
Possible CAS #: NA
Molecular form.: C₁₄H₁₉Cl₂N₃O₂S
Appearance: White to Off-White Solid
Melting Point: 238-242°C
Mol. Weight: 364.28
Storage: -20°C Freezer
Solubility: Methanol, Water
Stability: No Data Available
Category: Protein Kinase Inhibitors and Activators
Boiling Point: No Data Available
Applications: A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
Dangerous Goods Info: NA
References: Hidaka, H., et al.: Acta Nurochir. (Wien), 90 (1988) Sward., K., el a.: J. Physiol., 522, 33 (2000),
Peer Review Product Citations: Hidaka, H., et al.: Acta Nurochir. (Wien), 90 (1988) Sward., K., el a.: J. Physiol., 522, 33 (2000),

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  Pack size Price(USD)
10mg $55.00
100mg $375.00
1g $1475.00
  Pack size Price(USD)
25mg $110.00
500mg $875.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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