Isoniazid

Catalogue number: I821450
Chemical name: Isoniazid
Synonyms: 4-Pyridinecarboxylic Acid Hydrazide; Isonicotinic Acid Hydrazide; 4-(Hydrazinocarbonyl)pyridine; 4-Pyridinecarbonylhydrazine; 4-Pyridinecarboxylic Hydrazide; 4-Pyridylcarbonylhydrazide; 5015 R.P.; Armazid; Armazide; Atcotibine; Isonizide; Isotebezid; Isozide; Robisellin; Sauterazid; Zinadon; Zonazide; Tubazid;
CAS Number: 54-85-3
Possible CAS #: NA
Molecular form.: C₆H₇N₃O
Appearance: White Solid
Melting Point: 167-169°C
Mol. Weight: 137.14
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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