IQ 1

Catalogue number: I748570
Chemical name: IQ 1
Synonyms: 2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)-acetamide; 2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3,3-dimethyl-1(2H)- isoquinolinylidene)acetamide;
CAS Number: 331001-62-8
Possible CAS #: NA
Molecular form.: C₂₁H₂₂N₄O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 362.42
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: IQ 1 disrupts Wnt signaling. IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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