1-​(2-​Iodoethyl)​-​2-​octylbenzene

Catalogue number: I706320
Chemical name: 1-​(2-​Iodoethyl)​-​2-​octylbenzene
Synonyms: Fingolimod Impurity 8
CAS Number: 162358-96-5
Possible CAS #: NA
Molecular form.: C₁₆H₂₅I
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 344.27
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: 1-​(2-​Iodoethyl)​-​2-​octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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