Indirubin-3’-monoxime

Catalogue number: I527500
Chemical name: Indirubin-3’-monoxime
Synonyms: Indirubin-3’-oxime; 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one;
CAS Number: 160807-49-8
Possible CAS #: NA
Molecular form.: C₁₆H₁₁N₃O₂
Appearance: Dark Red Solid
Melting Point: 247-249°C (dec.)
Mol. Weight: 277.28
Storage: -20°C Freezer
Solubility: DMSO, Methanol
Stability: Light Sensitive
Category: Inhibitors
Boiling Point: No Data Available
Applications: A potent inhibitor of GSK-3ß (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10üM).
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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