iCRT-14

Catalogue number: I163900
Chemical name: iCRT-14
Synonyms: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione; iCRT 14; iCRT14;
CAS Number: 677331-12-3
Possible CAS #: NA
Molecular form.: C₂₁H₁₇N₃O₂S
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 375.44
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds,
Boiling Point: No Data Available
Applications: A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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