4-Hydroxy-PAC 1-β-D-Glucopyranosiduronic Acid

Catalogue number: H950180
Chemical name: 4-Hydroxy-PAC 1-β-D-Glucopyranosiduronic Acid
Synonyms: (2S,3S,4S,5R,6S)-6-(2-Allyl-4-((E)-(2-(2-(4-benzylpiperazin-1-yl)acetyl)hydrazono)methyl)-3-hydroxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₂₉H₃₆N₄O₉
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 584.62
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: No Data Available
Boiling Point: No Data Available
Applications: 4-Hydroxy-PAC 1-β-D-Glucopyranosiduronic Acid is a metabolite of PAC-1 (P132000), which is a potential anti-tumor drug candidate that activates caspase 3 and induces apoptosis in both in vitro and in vivo against mice tumors. Metabolites and derivatives of PAC-1 are useful compounds to investigate the mechanism of action and to serve as standards (ie. LC/MS). 
Dangerous Goods Info: NA
References: Ren, L., et al.: J. Chromatogr. B (2008); Slee, E., et al.: J. Biol. Chem., 276, 7320 (2001); Pop, C., et al.: Biochemistry, 42, 12311 (2003); Li, L., et al.: Science, 305, 1471 (2004); Green, D., et al.: J. Clin. Invest., 115, 2610 (2005); Satoh, T., et al.: Clin. Cancer Res., 15, 3872 (2009)
Peer Review Product Citations:

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