Catalogue number: H941625
Chemical name: 6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
Synonyms: (4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one; Lovastatin Diol Lactone; Monacolin J;
CAS Number: 79952-42-4
Possible CAS #: NA
Molecular form.: C₁₉H₂₈O₄
Appearance: White Solid
Melting Point: 104-114°C
Mol. Weight: 320.42
Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility: Chloroform, DMF, DMSO, Methanol
Stability: No Data Available
Category: Chiral Reagents, Drug Analogues, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: A Simvastatin intermediate; Lovastatin analog has the activities of decreasing blood cholesterol and low-d. lipoprotein, can be used to preparation hypolipidemic medicine.
Dangerous Goods Info: NA
References: Endo, A., et al.: J. Antibiot., 39, 1609 (1986), Aniya, Y., et al.: Gen. Pharmacol., 32, 225 (1999), Li, Y., et al.: J. Pharm. Biomed. Anal., 35, 1101 (2004), Akihisa, T., et al.: Chem. Biodivers, 2, 1305 (2005),
Peer Review Product Citations:

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