(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer)

Catalogue number: H938500
Chemical name: (Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer)
Synonyms: 4-[(1Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol; Endoxifen;
CAS Number: 112093-28-4
Possible CAS #: NA
Molecular form.: C₂₅H₂₇NO₂
Appearance: Off-White to Pink Solid
Melting Point: 127-129°C
Mol. Weight: 373.49
Storage: Amber Vial, -86°C Freezer, Under Inert Atmosphere
Solubility: Chloroform, Methanol
Stability: No Data Available
Category: Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
Dangerous Goods Info: Not a dangerous good if item is equal too or less than 1g/ml and there is less than 100g in the package
References: Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),
Peer Review Product Citations:

Order Product

  Pack size Price(USD)
.5mg $150.00
5mg $1325.00
  Pack size Price(USD)
1mg $275.00
10mg $2575.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   Pending QC

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