(R,R)-Hydroxy Des(boric Acid) Bortezomib

Catalogue number: H935910
Chemical name: (R,R)-Hydroxy Des(boric Acid) Bortezomib
Synonyms: N-((R)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
CAS Number: NA
Possible CAS #: NA
Molecular form.: C₁₉H₂₄N₄O₃
Appearance: Beige Solid
Melting Point: 107-109°C
Mol. Weight: 356.42
Storage: -20°C Freezer
Solubility: Chloroform, Methanol
Stability: No Data Available
Category: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: (R,R)-Hydroxy Des(boric Acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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