(S)-Hydroxy Des(boric Acid) Bortezomib

Catalogue number: H935905
Chemical name: (S)-Hydroxy Des(boric Acid) Bortezomib
Synonyms: N-[(1S)-2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-Pyrazinecarboxamide; N-[(1S)-2-[[(1S)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-pyrazinecarboxamide;
CAS Number: 289472-81-7
Possible CAS #: NA
Molecular form.: C₁₉H₂₄N₄O₃
Appearance: White to Off-White Solid
Melting Point: 125-127°C
Mol. Weight: 356.42
Storage: -20°C Freezer
Solubility: Chloroform, Methanol
Stability: No Data Available
Category: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: (S)-Hydroxy Des(boric Acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Dangerous Goods Info: NA
References: Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl, C. et al.: Chem. and Eng. News, 87, 41 (2009)
Peer Review Product Citations:

Order Product

  Pack size Price(USD)
.5mg $150.00
  Pack size Price(USD)
5mg $1200.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

Search Products:

Enter Catalogue #, CAS # , Chemical Name or Mol Formula:

Search By Category

Search By Category View products by category
Translate »