(R)-Hydroxy Des(boric Acid) Bortezomib

Catalogue number: H935900
Chemical name: (R)-Hydroxy Des(boric Acid) Bortezomib
Synonyms: N-[(1S)-2-[[(1R)-1-Hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide; N-[(1S)-2-[[(1R)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]pyrazinecarboxamide;
CAS Number: 289472-78-2
Possible CAS #: NA
Molecular form.: C₁₉H₂₄N₄O₃
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 356.42
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: (R)-Hydroxy Des(boric acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Dangerous Goods Info: NA
References: Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C. et al.: Chem. and Eng. News, 87, 41 (2009)
Peer Review Product Citations:

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