N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine

Catalogue number: H831225
Chemical name: N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine
Synonyms: HET-0016
CAS Number: 339068-25-6
Possible CAS #: NA
Molecular form.: C₁₂H₁₈N₂O
Appearance: Light Pink Solid
Melting Point: No Data Available
Mol. Weight: 206.28
Storage: No Data Available
Solubility: DMSO
Stability: No Data Available
Category: Aromatics
Boiling Point: No Data Available
Applications: HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A (IC50=8.9nM (human), 35nM (rat renal microsome). IC50 cyclooxygenase=2.3uM. IC50 for other CYP’s: CYP2C9-3.3uM, CYP2D6=83.9 uM, CYP3A4=71uM. It inhibits cerebrovascular constriction induced by Ca2+ or archidonate and inhibits angiogenesis and endothelial cell sprouting in various models. Displays protective effect on brain damage after temporary focal ischemia (at 10mg/Kg).
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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