4-Hydroxy Atorvastatin Hemicalcium Salt

Catalogue number: H828961
Chemical name: 4-Hydroxy Atorvastatin Hemicalcium Salt
Synonyms: (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-4-[[(4-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic Acid Hemicalcium Salt; p-Hydroxyatorvastatin Hemicalcium Salt
CAS Number: 1263176-34-6
Possible CAS #: free acid: 214217-88-6
Molecular form.: C₆₆H₆₈CaF₂N₄O₁₂
Appearance: Off-White to Light Beige Solid
Melting Point: >180°C (dec.)
Mol. Weight: 1187.34
Storage: Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
Solubility: Methanol
Stability: No Data Available
Category: Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: 4-Hydroxyatorvastatin is a hydroxylated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
Dangerous Goods Info: NA
References: Smith, S. et al.: Am. J. Cardiol., 80, 10H (1997); Jacobsen, W. et al.: Drug Metab. Dispos., 28, 1369 (2000); Istvan, E. et al.: Science, 292, 1160 (2001); Tabernero, L. et al.: J. Biol. Chem., 278, 19933 (2003); Bratton, L. et al.: Bioorg. Med. Chem., 15, 5576 (2007);
Peer Review Product Citations:

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