2-(2-Heptynylthio)phenol Acetate

Catalogue number: H288500
Chemical name: 2-(2-Heptynylthio)phenol Acetate
Synonyms: APHS
CAS Number: 209125-28-0
Possible CAS #: NA
Molecular form.: C₁₅H₁₈O₂S
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 262.37
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Inhibitors
Boiling Point: No Data Available
Applications: An O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and COX-2, with IC50 values of 17 and 0.8uM for human recombinant COX-1 and COX-2 respectively. APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of COX-1.
Dangerous Goods Info: NA
References: Kalgutkar, A.S., et a.: Science, 280, 1268 (1998)
Peer Review Product Citations: Kalgutkar, A.S., et a.: Science, 280, 1268 (1998)

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