H-1152 Dihydrochloride

Catalogue number: H011520
Chemical name: H-1152 Dihydrochloride
Synonyms: 5-[[(2S)-Hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methylisoquinoline Hydrochloride; (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]Homopiperazine Dihydrochloride;
CAS Number: 871543-07-6
Possible CAS #: NA
Molecular form.: C₁₆H₂₃Cl₂N₃O₂S
Appearance: White to Off-White Solid
Melting Point: 182-184°C
Mol. Weight: 392.34
Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility: Methanol, Water
Stability: No Data Available
Category: Inhibitors, Protein Kinase Inhibitors and Activators, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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