GSK PERK Inhibitor

Catalogue number: G797800
Chemical name: GSK PERK Inhibitor
Synonyms: 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone; 3-Fluoro-GSK2606414
CAS Number: 1337531-89-1
Possible CAS #: NA
Molecular form.: C₂₄H₁₉F₄N₅O
Appearance: Off-White to Pale Yellow Solid
Melting Point: 233-238°C (dec.)
Mol. Weight: 469.43
Storage: Refrigerator
Solubility: DMSO, Methanol (Sparingly)
Stability: No Data Available
Category: Aromatics, Heterocycles, Indole Derivatives, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: GSK PERK Inhibitor is an inhibitor of PERK, an important transmembrane protein of endoplasmic reticulum (ER). GSK PERK Inhibitor can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response pathways. As a result, GSK PERK Inhibitor has potential use in the treatment of diseases such as Alzheimer’s disease, stroke, Type 1 diabetes, Parkinson disease, Huntington’s disease, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, atherosclerosis, and arrhythmias, and more specifically cancers of the breast, colon, pancreatic, and lung.
Dangerous Goods Info: NA
References: Baltzis, D. et al.: J. Biol. Chem., 282, 31675 (2007); Axten, J. al,: J. Med. Chem. 55(16) 7193 (2012).
Peer Review Product Citations:

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  Pack size Price(USD)
1mg $110.00
5mg $125.00
25mg $475.00
  Pack size Price(USD)
2mg $115.00
10mg $245.00
50mg $900.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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