Genistein-2’,3’,5’,6’-d4 (Major)

Catalogue number: G350010
Chemical name: Genistein-2’,3’,5’,6’-d4 (Major)
Synonyms: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d4; Baichanin A-d4; Bonistein-d4; 4’,5,7-Trihydroxyisoflavone-d4; GeniVida-d4; Genisteol-d4; NSC 36586-d4; Prunetol-d4; Sophoricol-d4;
CAS Number: 187960-08-3
Possible CAS #: NA
Molecular form.: C₁₅H₆D₄O₅
Appearance: Light Yellow to Yellow Solid
Melting Point: >275°C (dec.)
Mol. Weight: 274.26
Storage: -20°C Freezer
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Inhibitors, Tyrosine Kinase Inhibitors, Isotope Labelled Compounds
Boiling Point: No Data Available
Applications: Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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