Genistein-2’,6’-d2

Catalogue number: G350005
Chemical name: Genistein-2’,6’-d2
Synonyms: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d2; Baichanin A-d2; Bonistein-d2; 4’,5,7-Trihydroxyisoflavone-d2; GeniVida-d2; Genisteol-d2; NSC 36586-d2; Prunetol-d2; Sophoricol-d2;
CAS Number: 315204-48-9
Possible CAS #: NA
Molecular form.: C₁₅H₈D₂O₅
Appearance: Pale Yellow Solid
Melting Point: 304-305°C dec.
Mol. Weight: 272.25
Storage: -20°C Freezer
Solubility: Acetone, DMSO, Ethyl Acetate
Stability: Light sensitive - Protect from light
Category: Inhibitors, Tyrosine Kinase Inhibitors, Isotope Labelled Compounds
Boiling Point: No Data Available
Applications: Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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10mg $880.00
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Exact Weight Packaging ($75(USD) / Vial)
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Inventory Status:   Pending QC

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