FTY720-d4 Hydrochloride

Catalogue number: F805002
Chemical name: FTY720-d4 Hydrochloride
Synonyms: 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol-d4 Hydrochloride; Fingolimod-d4 Hydrochloride;
CAS Number: 1346604-90-7
Possible CAS #: NA
Molecular form.: C₁₉H₃₀D₄ClNO₂
Appearance: White Solid
Melting Point: 105-107°C
Mol. Weight: 347.96
Storage: Refrigerator
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Aromatics, Inhibitors, Isotope Labelled Compounds, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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