Catalogue number: F595670
Chemical name: (E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)acrylaldehyde
Synonyms: (E)-3-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-2-propenal; (2E)-3-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-2-propenal; (E)-3-[3-(4-Fluorophenyl)-1-isopropylindol-2-yl]acrolein
CAS Number: 93957-50-7
Possible CAS #: NA
Molecular form.: C₂₀H₁₈FNO
Appearance: Yellow Solid
Melting Point: >132°C (dec.)
Mol. Weight: 307.36
Storage: Refrigerator, under inert atmosphere
Solubility: DMSO (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Aromatics, Miscellaneous Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: (E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)acrylaldehyde is an intermediate in the synthesis of Fluvastatin (F601250), a synthetic HMG-CoA reductase inhibitor. Antilipemic.
References: Sacharia, J.R., et. al.: J. Org. Chem., 75, 7514 (2010); Kim, A., Kim, I.S.: Bull. Korean Chem. Soc., 32, 3748 (2011); Yuan, J., et al.: Atherosclerosis, 87, 147 (1991); Tse, F.L.S., et al.: J. Clin. Pharmacol., 32, 630 (1992); Dain, J.G., et al.: Drug Metab. Disposit., 21, 567 (1993)
Dangerous Goods Info: NA

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