5-Fluoroorotic Acid Monohydrate-13C15N2

Catalogue number: F595002
Chemical name: 5-Fluoroorotic Acid Monohydrate-13C15N2
Synonyms: 5-FOA-13C15N2
CAS Number: NA
Possible CAS #: 703-95-7 unlabelled
Molecular form.: C₄¹³CH₅F¹⁵N₂O₅
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 195.08
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Isotope Labelled Compounds, Nucleotides, Bases & Related Reagents, 5-FOA
Boiling Point: No Data Available
Applications: 5-Fluoroorotic Acid Monohydrate-13C15N2 is the isotope analog of 5-Fluoroorotic Acid Monohydrate, (5-FOA). 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5’-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and
References: Winston, F., et al.: Genetics, 107, 179 (1984); Boeke, J.D., et al.: Methods Enzymol., 154, 164 (1987); Rathod, P.K., et al.: Antimicrob. Agents Chemother., 33, 1090 (1989); Rathod, P.K., et al.: Antimicrob. Agents Chemother., 36, 704 (1992); Gomez, Z.M . and Rathod, P.K.: Antimicrob. Agents Chemother., 34, 1371 (1990); Gassis, S. and Rathod, P.K.: Antimicrob. Agents Chemother., 40, 914 (1996)
Dangerous Goods Info: NA

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1mg $150.00
  Pack size Price(USD)
10mg $1200.00
Exact Weight Packaging ($75(USD) / Vial)
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