5-Fluoroorotic Acid Monohydrate

Catalogue number: F595000
Chemical name: 5-Fluoroorotic Acid Monohydrate
Synonyms: 5-FOA
CAS Number: 220141-70-8
Possible CAS #: 703-95-7
Molecular form.: C₅H₅FN₂O₅
Appearance: White to Off-White Solid
Melting Point: >255°C (dec.)
Mol. Weight: 192.1
Storage: -20°C Freezer
Solubility: 4M Aqueous Ammonium Hydroxide (Heated), DMSO (Slightly, Heated), Water (Slightly
Stability: No Data Available
Category: Nucleotides, Bases & Related Reagents, 5-FOA
Boiling Point: No Data Available
Applications: 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5’-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5
References: Winston, F., et al.: Genetics, 107, 179 (1984); Boeke, J.D., et al.: Methods Enzymol., 154, 164 (1987); Rathod, P.K., et al.: Antimicrob. Agents Chemother., 33, 1090 (1989); Rathod, P.K., et al.: Antimicrob. Agents Chemother., 36, 704 (1992); Gomez, Z.M . and Rathod, P.K.: Antimicrob. Agents Chemother., 34, 1371 (1990); Gassis, S. and Rathod, P.K.: Antimicrob. Agents Chemother., 40, 914 (1996)
Dangerous Goods Info: NA

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  Pack size Price(USD)
100mg $38.00
1g $85.00
10g $280.00
  Pack size Price(USD)
500mg $50.00
5g $190.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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