FK-506-13C,D2 (Major) (Tacrolimus) (>85%)

Catalogue number: F370002
Chemical name: FK-506-13C,D2 (Major) (Tacrolimus) (>85%)
Synonyms: Advagraf-13C,D2; FR 900506-13C,D2; Fujimycin-13C,D2; L 679934-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2;
CAS Number: 1356841-89-8
Possible CAS #: 104987-11-3 for unlabelled
Molecular form.: C₄₃¹³CH₆₇D₂NO₁₂
Appearance: White to Off-White Solid
Melting Point: 90-92°C
Mol. Weight: 807.02
Storage: -20°C Freezer, Under Inert Atmosphere
Solubility: Chloroform (Slightly), Methanol (Slightly)
Stability: No Data Available
Category: Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: A labelled immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. A representative lot contained a distribution of 20% d-1, 40% d-2 and 20% d-3.
Dangerous Goods Info: Not a dangerous good if item is equal too or less than 1g/ml and there is less than 100g in the package
References: Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., et al.: Brit. Med. J., 318, 1104 (1999),
Peer Review Product Citations:

Order Product

  Pack size Price(USD)
1mg $650.00
  Pack size Price(USD)
5mg $2750.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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