F-Amidine

Catalogue number: F101250
Chemical name: F-Amidine
Synonyms: N-[(1S)-1-(Aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]benzamide;
CAS Number: 877617-45-3
Possible CAS #: NA
Molecular form.: C₁₄H₁₉FN₄O₂
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 294.32
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point: No Data Available
Applications: An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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