5’-Ethylcarboxamido-2’,3’-isopropylidene Adenosine

Catalogue number: E900995
Chemical name: 5’-Ethylcarboxamido-2’,3’-isopropylidene Adenosine
Synonyms: 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide; 2’,3’-O-isopropylidene-NECA;
CAS Number: 39491-53-7
Possible CAS #: NA
Molecular form.: C₁₅H₂₀N₆O₄
Appearance: Pale Yellow Solid
Melting Point: 200-202˚C
Mol. Weight: 348.36
Storage: No Data Available
Solubility: DMSO, Ethanol, Methanol
Stability: No Data Available
Category: Carbohydrates & Derivatives, Heterocycles, Nucleotides, Bases & Related Reagents
Boiling Point: No Data Available
Applications: A useful template for the development of A2B adenosine receptor agonists. It was confirmed to be a full agonist in a functional assay based on the measurement of its capacity to modulate cAMP levels in CHO cells expressing the hA2B receptor.
Dangerous Goods Info: NA
References: Kemp, B., et al.: Br. J. Pharmacol., 126, 1796 (1999), Peyot, M., et al.: Circ. Res., 86, 76 (2000), Fredholm, B., et al.: Pharmacol. Rev., 53, 527 (2001), Zeng, D., et al.: Drug Dev. Res., 58, 405 (2003), Baraldi, P., et al.: J. Med. Chem., 47, 5535 (2004),
Peer Review Product Citations:

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