Epothilone D (synthetic)

Catalogue number: E589000
Chemical name: Epothilone D (synthetic)
Synonyms: (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione; (-)-Desoxyepothilone B; (-)-Epothilone D; 12,13-Deoxyepothilone B; 12,13-Desoxyepothilone B; Desoxyepothilone B; Epo D; Epothilone D; KOS 862; NSC 703147;
CAS Number: 189453-10-9
Possible CAS #: NA
Molecular form.: C₂₇H₄₁NO₅S
Appearance: White Solid
Melting Point: 63-66°C
Mol. Weight: 491.68
Storage: -20°C Freezer
Solubility: Chloroform (Slightly), DMSO (Slightly)
Stability: No Data Available
Category: Chiral Reagents, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells’ microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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