Epothilone B (synthetic)

Catalogue number: E588990
Chemical name: Epothilone B (synthetic)
Synonyms: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; (-)-Epothilone B; EPO 906; EPO 906A; Epothilone B; Patupilone;
CAS Number: 152044-54-7
Possible CAS #: NA
Molecular form.: C₂₇H₄₁NO₆S
Appearance: White Solid
Melting Point: 95-97°C
Mol. Weight: 507.68
Storage: -20°C Freezer, Under Inert Atmosphere
Solubility: Chloroform, Dichloromethane, DMSO, Ethanol, Methanol
Stability: No Data Available
Category: Chiral Reagents, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Boiling Point: No Data Available
Applications: Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
Dangerous Goods Info: NA
References:
Peer Review Product Citations:

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