ENMD 547

Catalogue number: E555800
Chemical name: ENMD 547
Synonyms: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone Hydrobromide; 1-(6-Amino-1-oxohexyl)-4-(3-methyl-1-oxobutyl)piperazine Monohydrobromide;
CAS Number: 644961-61-5
Possible CAS #: NA
Molecular form.: C₁₅H₃₀BrN₃O₂
Appearance: N/A
Melting Point: No Data Available
Mol. Weight: 364.32
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.
Dangerous Goods Info: NA
References: Kelso, E.B., et al.: J. Pharmacol. Exp. Ther., 316, 1017 (2006), Kelso, E.B., et al.: Arthritis Rheum., 56, 765 (2007),
Peer Review Product Citations:

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20mg $120.00
  Pack size Price(USD)
200mg $960.00
Exact Weight Packaging ($75(USD) / Vial)
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