Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
No Data Available
A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.
Dangerous Goods Info:
Kelso, E.B., et al.: J. Pharmacol. Exp. Ther., 316, 1017 (2006), Kelso, E.B., et al.: Arthritis Rheum., 56, 765 (2007),