EB 47

Catalogue number: E320300
Chemical name: EB 47
Synonyms: 5’-Deoxy-5’-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5’-oxoadenosine; 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D- ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide
CAS Number: 366454-36-6
Possible CAS #: NA
Molecular form.: C₂₄H₂₇N₉O₆
Appearance: No Data Available
Melting Point: No Data Available
Mol. Weight: 537.53
Storage: No Data Available
Solubility: No Data Available
Stability: No Data Available
Category: Heterocycles, Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point: No Data Available
Applications: EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult.
Dangerous Goods Info: NA
References: Jagtap, et al.: Bioorg. Med. Chem. Lett., 14, 81 (2004), Gaymes, et al.: Haematologica, 94, 638 (2009), Ferraris, et al.: J. Med. Chem. 53, 4561 (2010),
Peer Review Product Citations:

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