Dorsomorphin Dihydrochloride

Catalogue number: D534910
Chemical name: Dorsomorphin Dihydrochloride
Synonyms: 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Dihydrochloride; 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine Hydrochloride (1:2)
CAS Number: 1219168-18-9
Possible CAS #: NA
Molecular form.: C₂₄H₂₇Cl₂N₅O
Appearance: Yellow Solid
Melting Point: 62-66°C
Mol. Weight: 472.41
Storage: Hygroscopic, Refrigerator, under inert atmosphere
Solubility: DMSO, Water
Stability: No Data Available
Category: Aromatics, Protein Kinase Inhibitors and Activators
Boiling Point: No Data Available
Applications: Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
Dangerous Goods Info: NA
References: Shen, Q.W., Gerrard, D.E., Du, M.: Meat Sci., 78, 323 (2008); Yu, P., et. al.: Nat. Chem. Biol., 4, 33 (2008); Kim, H., et. al.: J. Biol. Chem., 283, 3731 (2008)
Peer Review Product Citations:

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  Pack size Price(USD)
10mg $130.00
  Pack size Price(USD)
50mg $425.00
Exact Weight Packaging ($75(USD) / Vial)
Inventory Status:   In Stock

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